Lalacewar Huhu ta Busulfan: Duk abin da kuke buƙatar sani game da areananan Cutar da ke Sama Sama ruwan hoda ne

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Sabon fim din Bollywood 'Sky Is Pink' yana cikin labarai saboda duk wasu dalilai da suka dace. Dangane da ainihin labarin rayuwar Aisha Chaudhary, fim din ya ta'allaka ne game da yanayin rashin lafiya, Busulfan ya haifar da lalacewar huhu ko huhu wanda ya haifar da mutuwar ajiyar Aisha a lokacin yana matashi ɗan shekara 18.

Yarinyar da aka haifa tare da rashin cikakkiyar kariya ta rashin ƙarfi (SCID), an buƙaci yarinyar ta yi aikin dashen ƙashi a cikin watanni 6, lokacin da aka saka ta a kan Busulfan (maganin ciwon daji). Magungunan ya ci gaba da haifar da fibrosis na huhu wanda ke da tasirin tasirin magani.

Kafin mu fahimci abin da cutar Busulfan ta haifar da cutar huhu da bayanan ta, bari muyi nazari kan SCID.

Menene Cikakken Hadaddiyar Rashin Imani (SCID)?

Cutar da ke da alaƙa da ƙwayar cuta, SCID tana tattare da rikicewar rikicewar ƙwayoyin T da ke aiki da ƙwayoyin B, sakamakon sauye-sauyen halittu masu yawa. Yanayin ya sa yaro ya ragu sosai ko kuma ba shi da rigakafi kwata-kwata, yana sa jikin yaron zama mai saukin kamuwa da cututtuka daban-daban ^{[1] [biyu]} .

Yaran da ke da wannan cututtukan na gado, suna fama da rashin lafiya kamar cututtukan huhu, sankarau, da kaza kuma suna iya mutuwa cikin shekarar farko ta rayuwarsu. Koyaya, magungunan zamani da hanyoyin magani sun taimaka inganta.

Dashen kasusuwan kasusuwa shine magani mafi inganci ga SCID ^[3] .

mafi kyawun fakitin fuska don kuraje

Don haka, Menene Sanya Kashin Kashi?

Marwayar ƙwayar jijiya wani magani ne da ke maye gurbin ɓargo mara ƙoshin lafiya da mai lafiya. Kashin kashin nama shine laushi, nama mai laushi a cikin kashin ka wanda yake sanya kwayoyin halitta (sel masu jini) wadanda suka rikide zuwa kwayoyin jini dan yakar cutuka, daukar iskar oxygen cikin jiki da kuma kula da zubar jini ^[4] .

Ana yin dashen ne don sanya lafiyayyan kwayoyin halittar kasusuwa cikin mutum bayan an kawar da kashin jikinsu mara lafiya, kuma yana da amfani wajen inganta garkuwar jikin yaro ^[5] .

Tare da yalwar amfanin da dasawar ke da shi kan inganta lafiyar mutum, hakanan ma yana da rikitarwa da dama irin su cutar ta hanyar daki-daki, karyewar kwayar halitta, lalacewar sassan jiki, cututtuka, cututtukan ido, rashin haihuwa, sabbin cututtukan daji har ma da mutuwa. ^{[6] [1]} .

Busulfan magani ne na rigakafin cutar sankara wanda ake amfani dashi a aikin dashen ƙashi. Koyaya, akwai rahotanni game da miyagun ƙwayoyi suna da mummunan tasiri ga mutanen da aka yiwa dashen, tare da fibrosis na huhu shine mafi tsananin.

Yanzu tunda mun rufe filayen, bari muyi la’akari da mahimmin taken, ‘lalacewar huhu da Busulfan ya haifar’ kuma don haka, ya kamata mu san menene Busulfan da yadda yake aiki ^[7] .

Menene Busulfan?

Magunguna ne da ake amfani da su don magance cututtukan daji da lalata ɓarkewar kashin da ba a so kafin a sauya ɓargazar ƙashi. Magungunan ƙwayar ƙwayar cuta yana cikin ƙungiyar magunguna da ake kira alkylating agents kuma yana aiki ta hanyar rage gudu ko dakatar da haɓakar ƙwayoyin kansa a cikin jikinku ^[8] . Hakanan ana amfani dashi don magance wasu cututtukan jini kamar polycythemia vera da myeloid metaplasia kuma don magance cutar sankarar myelogenous na yau da kullun (CML) ^[9] .

Koyaya, magani na chemotherapy, kamar yadda aka ambata ɗazu yana da sakamako mai illa wanda ke haifar da fibrosis na huhu wanda ake kira da lalacewar huhu na Busulfan ^{[9] [10]} .

Menene Lalacewar Huhu na Busulfan?

Busulfan huhu, wanda aka fi sani da asibiti a matsayin fibrosis na huhu yana haifar da magani inda ƙwayar huhun ta lalace da tabo. Kodayake ba safai ba, yanayin na mutuwa ne kuma yana faruwa a ƙasa da kashi 5 cikin 100 na marasa lafiyar da aka yiwa Busulfan magani ^{[goma sha]} . Rahoton farko na lalacewar huhu na Busulfan an ruwaito shi a cikin 1961.

maganin dabi'a na maganin gashi

Yanayin yana sa a samar da zazzaɓi masu kauri da ƙarfi a cikin huhu, wanda hakan ke sa mutum ya yi wuya ya numfasa.

Amma, ya kamata a lura cewa magani yana da wasu cututtukan sakamako masu tsanani, kamar waɗannan masu zuwa ^[12] :

• Zubar da jini
• Rashin ƙarfi
• Ciwon ido
• Magungunan atrophy
• Amenorrhoea
• Lalacewar tayi
• Rashin ƙarfi
• Fibrosis na huhu
• Bayyanar da sinadarin uric acid a cikin kodar koda
• Anemia
• Alopecia
• Gynaecomastia

Wasu daga cikin laushin tasirin maganin sune kamar haka ^{[goma sha]} :

• Rage nauyi
• Ciwan mara
• Perunƙwasawar fata
• Amai
• Gudawa
• Rashes
• Gajiya
• Bakin bushe

Ta Yaya Ake Binciko Lalacewar Huhu ta Busulfan?

Ganin cewa magani ne ya haifar da yanayin, yana da wuya a gano yanayin. Kuma a mafi yawan lokuta, yanayin zai kasance a matakinsa na ci gaba.

Oididdigar ƙididdigar ƙirar ƙira mai girma (CT Scan) da histopathology sune mafi kusa hanyoyin da zasu iya taimakawa gano asali ^[13] . A wasu lokuta na lalacewar huhu na Busulfan, masu bincikar cutar sun bayyana abubuwa masu zuwa:

• Rage carbon monoxide (CO) sakewar aiki
• Tsarin ƙuntataccen numfashi akan gwajin aikin huhu
• X-ray ɗin kirji na iya nuna bazuwar launuka da faci a gaɓoɓin huhun huhu
• Kasancewar rales
• Launin shuɗin lebe, fata, ko farce saboda ƙarancin iskar oxygen
• Abara girman al'ada na farcen yatsa

A Bayanin Karshe ...

Idan yanayin ya kasance a farkon matakan, to ya fi sauƙi a iya sarrafa maganin ƙwayar cuta na huhu - kamar yadda za a iya dakatar da maganin ƙwayoyi na yanzu kuma za a iya fara sabon magani ^{[14] [goma sha biyar]} .

Koyaya, dole ne a gudanar da ƙarin karatu akan fahimtar yanayin cutar mai haɗari da haɓaka ingantaccen maganin likita iri ɗaya.

1. [1]De Ravin, S. S., Wu, X., Moir, S., Kardava, L., Anaya-O'Brien, S., Kwatemaa, N., ... & Marquesen, M. (2016). Maganin kwayar halitta mai tsinkayyar kwayar halitta ta jini don rashin haɗin rashin ƙarfi mai nasaba da haɗin X. Kimiyyar fassara ta kimiyya, 8 (335), 335ra57-335ra57.
2. [biyu]Palacios, T. V., Vergales, B., Wisniewski, J., Borish, L., & Lawrence, M. G. (2016). Jami'ar Virginia tana da ƙwarewa wajen aiwatar da gwajin haihuwa don ƙarancin haɓakar rashin ƙarfi (SCID). Jaridar Allergy da Clinical Immunology, 137 (2), AB216.
3. [3]Sundin, M., Marits, P., Ramme, K., Kolios, A. G., & Nilsson, J. (2019). Combinedarancin haɓakar rashin ƙarfi (SCID) wanda ke gabatarwa a ƙuruciya, tare da agammaglobulinemia, wanda ke da alaƙa da sabon maye gurbi na maye gurbin heterozygous a cikin DCLRE1C. Immunology na Clinical, 200, 16-18.
4. [4]Klein, O. R., Buddenbaum, J., Tucker, N., Chen, A. R., Gamper, C.J, Loeb, D., ... & Holuba, M. J. (2017). Munƙasar ɓarkewar ɓarkewar ɓarke ​​mai haɗuwa tare da maye gurbin cyclophosphamide don ƙwararrun yara da ƙwararrun matasa tare da mummunan haɗarin cututtukan jini. Ilimin halittar jini da dashen Marrow, 23 (2), 325-332.
5. [5]Robinson, T. M., O'Donnell, P. V., Fuchs, EJ, & Luznik, L. (2016, Afrilu). Bonearjin ƙashin ƙashi da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta: ƙwarewa tare da cyclophosphamide bayan sake dasawa. A cikin Taron karawa juna sani a fannin ilimin jini (Vol. 53, No. 2, shafi na 90-97). WB Saunders.
6. [6]Morishima, Y., Kashiwase, K., Matsuo, K., Azuma, F., Morishima, S., Onizuka, M., ... & Mori, T. (2015). Mahimmancin ilimin halitta na HLA wuri wanda ya dace a cikin ɓangaren haɗin mai ba da alaƙa. Jini, 125 (7), 1189-1197.
7. [7]Ikeda, J., Scipione, C., Hyduk, S., Althagafi, M. G., Gao, X., Jongstra-Bilen, J., & Cybulsky, M. I. (2019). Yin dashen Kashi na Kashi Yana tasiri Matsayi na farko na Samuwar Cutar Atherosclerotic. Arteriosclerosis, Thrombosis, da Ilimin Halitta, 39 (Suppl_1), A534-A534.
8. [8]Bezinelli, L. M., Eduardo, F. P., De Carvalho, D.LC, dos Santos Ferreira, C.E, De Almeida, E. V., Sanches, L. R., ... & Corrêa, L. (2017). Kula da lafiyar yau da kullun na busulfan na IV a cikin marasa lafiyar da ke fama da dashen kwayar halitta ta hematopoietic: nazarin matukin jirgi. Dasawar kasusuwa, 52 (10), 1384.
9. [9]Tutschka, P.J, Copelan, E. A., & Klein, J. P. (1987). Yin dashen kasusuwan kashi don cutar sankarar jini bayan bin sabon busulfan da tsarin cyclophosphamide. Jini, 70 (5), 1382-1388.
10. [10]Jain, R., Gupta, K., Bhatia, A., Bansal, A., & Bansal, D. (2017). Ciwon cututtukan cututtukan zuciya na hanta da ciwon huhu na busulfan a cikin mai karɓar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta. Pwararrun likitocin Indiya, 54 (9), 765-770.
11. [goma sha]Matijasic, N., Bonevski, A., Tokic Pivac, V., & Pavic, I. (2019). Raunin Raunin Raunin Busulfan da ke Cikin Marassa lafiyar Ilimin Yara na Ilimin Yara - Nazarin Litattafai tare da Halin Kwatanci. Allergy na yara, Immunology, da Pulmonology, 32 (3), 86-91.
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13. [13]Rix, A., Drude, N. I., Mrugalla, A., Baskaya, F., Pak, K. Y., Gray, B., ... & Mottaghy, F. M. (2019). Bincike na lalacewar ƙwayoyin cuta na Chemotherapy tare da Ga-68 Label mai suna Duramycin. Halin kwayoyin halitta da ilmin halitta, 1-11.
14. [14]Themanns, M., Koban, F., Bergmayr, C., Chrzan, A., Strohmaier, W., Haybaeck, J., ... & Zebedin-Brandl, E. (2019). Treprostinil yana rage lalacewar endothelial a cikin cututtukan toshewar murus na murine. Jaridar Magungunan Magunguna, 97 (2), 201-213.
15. [goma sha biyar]Averyanov, A., Kogan, E., & Lesnyak, V. (2020). Kwayoyin cututtukan huhu da ke haifar da ƙwayoyi A cikin Wahala don Gano Cutar Yututtukan Hankali (shafi na 393-408). Cibiyar Nazari.

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